PMS: THE HORMONE IMBALANCE THEORY
It seemed obvious when PMS was first recorded in the medical textbooks that it must have a hormonal cause. Since PMS only occurs during the luteal phase of the menstrual cycle (in the two weeks before a period), research has focused on the hormones at that time of the month.
At this time of the cycle, levels of oestrogen drop markedly, while levels of progesterone are usually fairly high. There are two camps in the hormone debate. One side says that PMS is caused by a lack of oestrogen. The other says that PMS is caused by lack of progesterone.
The oestrogen theory. Support for an oestrogen deficiency has come from studies of women who have had their normal menstrual cycle stopped. Doctors do this either by giving women a drug that blocks the action of GnRH (the hormone that controls the regulation of the menstrual cycle) or surgery to remove the womb and ovaries.
When the menstrual cycle is stopped women do not get PMS. If women are then given oestrogen-replacement therapy they still do not develop symptoms. If, however, they are given progesterone, or its artificial form progestogen, they develop PMS-like symptoms.
Doctors who believe that PMS is caused by a lack of oestrogen tend to treat women with oestrogen therapy.
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Womens health
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